Research paper


Ochi Y, Kon A, Sakata T, Nakagawa MM, Nakazawa N, Kakuta M, Kataoka K, Koseki H, Nakayama M, Morishita D, Tsuruyama T, Saiki R, Yoda A, Okuda R, Yoshizato T, Yoshida K, Shiozawa Y, Nannya Y, Kotani S, Kogure Y, Kakiuchi N, Nishimura T, Makishima H, Malcovati L, Yokoyama A, Takeuchi K, Sugihara E, Sato TA, Sanada M, Takaori-Kondo A, Cazzola M, Kengaku M, Miyano S, Shirahige K, Suzuki HI, Ogawa S.  “Combined Cohesin-Runx1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes.”
Cancer Discovery, 2020 Apr 5. pii: CD-19-0982. doi: 10.1158/2159-8290.CD-19-0982. [Epub ahead of print]


Linke P, Suzuki R, Yamamoto A, Nakahata M, Kengaku M, Fujiwara T, Ohzono T, Tanaka M. “Dynamic Contact Guidance of Myoblasts by Feature Size and Reversible Switching of Substrate Topography: Orchestration of Cell Shape, Orientation, and Nematic Ordering of Actin Cytoskeletons.”
Langmuir, 35(23), 7538-7551 (2019) doi: 10.1021/acs.langmuir.8b02972.


Kawabata Galbraith K, Fujishima K, Mizuno H, Lee SJ, Uemura T, Sakimura K, Mishina M, Watanabe N and Kengaku M. “MIM regulation of actin-nucleating formin DAAM1 in dendritic filopodia determines final dendritic configuration of Purkinje cells.”
Cell Rep, 24(1), 95-106. e9. (2018) doi: 10.1016/j.celrep.2018.06.013.

Umeshima H, Nomura KI, Yoshikawa S, Hörning M, Tanaka M, Sakuma S, Arai F, Kaneko M and Kengaku M. “Local traction force in the proximal leading process triggers nuclear translocation during neuronal migration.”
Neurosci Res, 142, 38-48 (2018) doi: 10.1016/j.neures.2018.04.001.

Wu YK, Umeshima H, Kurisu J and Kengaku M. “Nesprins and opposing microtubule motors generate a point force that drives directional nuclear motion in migrating neurons.”
Development, 145(5), pii:dev158782. (2018) doi: 10.1242/dev.158782.
Featured article (The Node interviews)


Nakatsuji H, Kawabata Galbraith K, Kurisu J, Imahori H, Murakami T and Kengaku M. “Surface chemistry for cytosolic gene delivery and photothermal transgene expression by gold nanorods.”
Sci. Rep, 7(1),4694 (2017) doi: 10.1038/s41598-017-04912-1.

Hatsukano T, Kurisu J, Fukumitsu K, Fujishima K and Kengaku M. “Thyroid hormone induces PGC-1 α during dendritic outgrowth in mouse cerebellar Purkinje cells.”
Front. Cell. Neurosci, 11,133 (2017) doi: 10.3389/fncel.2017.00133.


Takano Y, Numata T, Fujishima K, Miyake K, Nakao K, Grove WD, Inoue R, Kengaku M, Sasaki S, Mori Y, Murakami T and Imahori H. “Optical control of neuronal firing via photoinduced electron transger in donor-acceptor conjugates.”
Chem. Sci, 7(5),3331-3337 (2016) doi: 10.1039/c5sc04135j.

Fukumitsu K, Hatsukano T, Yoshimura A, Heuser J, Fujishima K and Kengaku M.
“Mitochondrial fission protein Drp1 regulates mitochondrial transport and dendritic arborization in cerebellar Purkinje cells.”
Mol Cell Neurosci, 71,56-65 (2016) doi: 10.1016/j.mcn.2015.12.006.


Oomoto I, Suzuki-Hirano A, Umeshima H, Han YW, Yanagisawa H, Carlton P, Harada Y, Kengaku M, Okamoto A, Shimogori T and Wang DO. “ECHO-liveFISH: in vivo RNA labeling reveals dynamic regulation of nuclear RNA foci in living tissues.”
Nucleic Acids Res, 43(19),e126 (2015) doi: 10.1093/nar/gkv614.

Nakashima K, Umeshima H and Kengaku M. “Cerebellar granule cells are predominantly generated by terminal symmetric divisions of granule cell precursors.”
Dev Dyn, 244(6), 748-758 (2015) doi: 10.1002/dvdy.24276.

Fukumitsu K, Fujishima K, Yoshimura A, Wu YK, Heuser J and Kengaku M. “Synergistic action of dendritic mitochondria and creatine kinase maintains ATP homeostasis and actin dynamics in growing neuronal dendrites.”
J Neurosci, 35(14), 5707-5723 (2015) doi: 10.1523/JNEUROSCI.4115-14.2015. Cover Article

Wu YK, Fujishima K and Kengaku M. “Differentiation of Apical and Basal Dendrites in Pyramidal Cells and Granule Cells in Dissociated Hippocampal Cultures.”
PLoS ONE, 10(2),e0118482 (2015) doi: 10.1371/journal.pone.0118482.


Bando Y, Irie K, Shimomura T, Umeshima H, Kushida Y, Kengaku M, Fujiyoshi Y, Hirano T. and Tagawa Y. “Control of spontaneous Ca2+ transients is critical for neuronal maturation in the developing neocortex.”
Cereb Cortex, 26(1),106-117 (2016) doi: 10.1093/cercor/bhu180. Epub 2014 Aug 11.

Kumeta M, Gilmore JL, Umeshima H, Ishikawa M, Kitajiri S. Horigome T, Kengaku M. and Takeyasu, K. “Caprice/MISP is a novel F-actin bundling protein critical for actin-based cytoskeletal reorganizations.”
Genes Cells, 19(4), 338- 349 (2014)  doi: 10.1111/gtc.12131. 

Shimono K, Fujishima K, Nomura T, Ohashi M, Usui T, Kengaku M, Toyoda A and Uemura T. “An evolutionarily conserved protein CHORD regulates scaling of dendritic arbors with body size.”
Sci Rep, 19;4:4415 (2014)  doi: 10.1038/srep04415.


Umeshima H and Kengaku M. “Differential roles of cyclin-dependent kinase 5 in tangential and radial migration of cerebellar granule cells.”
Mol Cell Neurosci, 52, 62-72 (2013) doi: 10.1016/j.mcn.2012.08.005.


Tomioka M, Toda Y, Kurisu J, Kimura Y, Kengaku M and Ueda K. “The Effects of Neurological Disorder-Related Codon Variations of ABCA13 on the Function of the ABC Protein.”
Biosci Biotechnol Biochem, 76(12), 2289-2293 (2012)

Fujishima K, Horie R, Mochizuki A and Kengaku M. “Principle branch dynamics governing shape characteristics of cerebellar Purkinje cell dendrites.”
Development, 139(18), 3442-3455 (2012) doi: 10.1242/dev.081315. Featured Movie


Kaneko M, Takata N, Eiraku M, Kiyohara Y, Aida T, Hirase H, Hashikawa T and Kengaku M. “Monoplanar arborization of Purkinje cell dendrites is regulated by afferent climbing fiber inputs.”
PLoS ONE, 6(5), e20108 (2011) doi: 10.1371/journal.pone.0020108.


Sasaki N, Kurisu J and Kengaku M. “Sonic hedgehog signaling regulates actin cytoskeleton via Tiam1-Rac1 cascade during spine formation.”
Mol Cell Neurosci, 45(4), 335-344 (2010) doi: 10.1016/j.mcn.2010.07.006. 

Kurisu J, Fukuda T, Yokoyama S, Hirano T and Kengaku M. “Polarized targeting of DNER into dendritic plasma membrane in hippocampal neurons depends on endocytosis.”
J Neurochem, 113(6), 1598-1610 (2010) doi: 10.1111/j.1471-4159.2010.06714.x.

Shimono K, Sugimura K, Kengaku M, Uemura T and Mochizuki A. “Computational modeling of dendritic tiling by diffusible extracellular suppressor.”
Genes Cells, 15(2), 137-149 (2010) doi: 10.1111/j.1365-2443.2009.01367.x.


Yamada M, Yoshida Y, Mori D, Takitoh T, Kengaku M, Umeshima H, Takao K, Miyakawa T, Sato M, Sorimachi H, WynshawBoris A and Hirotsune S.
“Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly.”
Nat Med, 15(10), 1202-1207 (2009) doi: 10.1038/nm.2023.

Fukazawa N, Yokoyama S, Eiraku M, Kengaku M and Maeda N.
“Receptor type protein tyrosine phosphatase zeta-pleiotrophin signaling controls endocytic trafficking of DNER that regulates neuritogenesis.”
Mol Cell Biol, 28(14), 4494-4506 (2008) doi: 10.1128/MCB.00074-08.

Umeshima H, Hirano T and Kengaku M. “Microtubule-based nuclear movement occurs independently of cetrosome positioning in migrating neurons.”
Proc Natl Acad Sci U S A, 104(41), 16182-16187 (2007) Must Read Article by Faculty of 1000

Fujishima K, Kiyonari H, Kurisu J, Hirano T and Kengaku M. “Targeted disruption of Sept3, a heteromeric assembly partner of Sept5 and Sept7 in axons, has no effect on developing CNS neurons.”
J Neurochem, 102(1), 77-92 (2007)

Yawata S, Tsuchida H, Kengaku M and Hirano T. “Membrane-proximal region of glutamate receptor delta2 subunit is critical for long-term depression and interaction with protein interacting with C kinase 1 in a cerebellar purkinje neuron.”
J Neurosci, 26(14), 3626-3633 (2006) Erratum in: J Neurosci. 26(16),4451 (2006)

Su HL, Muguruma K, Matsuo-Takasaki M, Kengaku M, Watanabe K and Sasai Y.
“Generation of cerebellar neuron precursors from embryonic stem cells.”
Dev Biol, 290(2), 287-296 (2006)

Tohgo A, Eiraku M, Miyazaki T, Miura E, Kawaguchi S, Nishi M, Watanabe M, Hirano T, Kengaku M and Takeshima T. “Impaired cerebellar functions in mutant mice lacking DNER.”
Mol Cell Neurosci, 31(2), 326-333 (2006)

Eiraku M, Tohgo A, Ono K, Fujishima K, Kaneko M, Hirano T and Kengaku M.
“DNER acts as a neuron-specific Notch ligand during Bergmann glial development.”
Nat Neurosci, 8(7), 873-880 (2005) Must Read Article by Faculty of 1000 (FFa: 8)

Shima Y, Kengaku M, Hirano T, Takeichi M and Uemura T. “Regulation of Dendritic Maintenance and Growth by a Mammalian 7-pass Transmembrane Cadherin.”
Dev Cell, 7(2), 205-216 (2004)

Kawaji K, Umeshima H, Eiraku M, Hirano T and Kengaku M.
“Dual modes of migration of cerebellar granule cells guided by axonal and dendritic leading processes.”
Mol Cell Neurosci, 25(2), 228-240 (2004)

Minami I, Kengaku M, Smitt PS, Shigemoto R and Hirano T. “Long-term potentiation of mGluR1 activity by depolarization-induced Homer1a in mouse cerebellar Purkinje neurons.”
Eur J Neurosci, 17(5), 1023-1032 (2003)

Eiraku M, Hirata Y, Takeshima H, Hirano T and Kengaku M. “Delta/Notch-like EGF-related Receptor (DNER), a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons.”
J Biol Chem, 277(28), 25400-25407 (2002)

Yamasaki T, Kawaji K, Bito H, Hirano T, Osumi N and Kengaku M. “Pax6 regulates granule cell polarization during parallel fiber formation in the developing cerebellum.”
Development, 128(16), 3133-3144 (2001)

Haraguchi R, Suzuki K, Murakami R, Sakai M, Kamikawa M, Kengaku M, Sekine K, Kawano H, Kato S, Ueno N and Yamada G. “Molecular analysis of external genitalia formation: the role of fibroblast growth factor (Fgf) genes during genital tubercle formation.”
Development, 127(11), 2471-2479 (2000)

Hongo I, Kengaku M and Okamoto H. “FGF signaling and the anterior neural induction in Xenopus.”
Dev Biol, 216(2), 561-581 (1999)

Kengaku M, Capdevila J, Rodriguez-Esteban C, De La Peña J, Johnson RL, Belmonte JC and Tabin CJ. “Distinct Wnt pathways regulating AER formation and dorsoventral polarity in the chick limb bud.”
Science, 280(5367), 1274-1277 (1998)

Kengaku M, Twombly V and Tabin C. “Expression of Wnt and Frizzled genes during chick limb bud development.”
Cold Spring Harb Symp Quant Biol, 62, 421-429 (1997)

Kengaku M and Okamoto H. “bFGF as a possible morphogen for the anteroposterior axis of the central nervous system in Xenopus.”
Development, 121(9), 3121-3130 (1995)

Kengaku M and Okamoto H. “Basic fibroblast growth factor induces differentiation of neural tube and neural crest lineages of cultured ectoderm cells from Xenopus gastrula.”
Development, 119(4), 1067-1078 (1993)

Kengaku M, Misawa H and Deguchi T. “Multiple mRNA species of choline acetyltransferase from rat spinal cord.”
Brain Res Mol Brain Res, 18(1-2), 71-76 (1993)

Kengaku M, Kawata A, Kawashima S and Nakane M. “Role of fibronectin in the inhibitory effect of TGF-ß on choline acetyltransferase activity in co-cultures of spinal cord neurons and myotubes.”
Brain Res Dev Brain Res, 61(2), 281-284 (1991)

Kengaku M, Kawashima S and Nakane M. “Expression of choline acetyltransferase activity in a co-culture of spinal cord and skeletal muscle cells is inhibited by myogenic differentiation inhibitors.”
Brain Res Dev Brain Res, 60(2), 133-136 (1991)

Hara E, Fukatsu T, Kakeda K, Kengaku M, Ohtaka C and Ishikawa H.
The predominant protein in an aphid endosymbiont is homologous to an E. coli heat shock protein.
Symbiosis, 8(3), 271-283 (1990)

Review papers


Nakazawa N and Kengaku M (2020) “Mechanical regulation of nuclear translocation in migratory neurons.
Front. Cell Dev. Biol. 8:150. doi: 10.3389/fcell.2020.00150

Kawabata Galbraith K, Kengaku M (2019) “Multiple roles of the actin and microtubule-regulating formins in the developing brain.”
Neurosci. Res., 2019 Jan;138:59-69. doi: 10.1016/j.neures.2018.09.008. Epub 2018 Sep 15.

Kengaku M (2018) “Cytoskeletal control of nuclear migration in neurons and non-neuronal cells”
Proc Jpn Acad Ser B Phys Biol Sci., 10.2183/pjab.94.022 Cover Article

Fujishima K, Kawabata Galbraith K, Kengaku M (2018) “Dendritic Self-Avoidance and Morphological Development of Cerebellar Purkinje Cells.”
Cerebellum, 2018 Dec;17(6):701-708. doi: 10.1007/s12311-018-0984-8.

Wu YK, Kengaku M (2018) “Dynamic Interaction Between Microtubules and the Nucleus Regulates Nuclear Movement During Neuronal Migration.”
J Exp Neurosci. 2018 Jul 16;12:1179069518789151. doi: 10.1177/1179069518789151. eCollection 2018.

Kengaku M (2009) “Neuronal migration.”
Encyclopedia of Neuroscience, 2009 Edition


中澤 直高、見学美根子(2019) ”脳発生に寄与するニューロン遊走のメカノバイオロジー” 生体の科学 特集 メカノバイオロジー vol. 70 No.4, 317-321. 公益財団法人金原一郎記念医学医療振興財団/医学書院

梅嶋宏樹、見学美根子(2018)”23章 細胞移動と脳層構造の形成” 脳神経化学 –脳はいま化学の言葉でどこまで語れるか–PartⅣ 脳神経系の高次機能・構造をコントロールする分子群、241-253. 化学同人

今井猛、見学美根子(2018)“11章 身体の司令塔 脳と神経” 京大発!フロンティア生命科学、169-177、講談社

藤島和人、見学美根子(2012)”樹状突起極性形成に関する最近の知見” 生体の科学 特集 細胞極性の制御 vol.63(3):163-170. 公益財団法人金原一郎記念医学医療振興財団/医学書院

見学美根子(2012)”数理解析による樹状突起分岐ダイナミクスとパターン形成原理の解明” ブレインサイエンス・レビュー2012, (財)ブレインサイエンス振興財団, クバプロ, 25-40

見学美根子(2007)”脳形成を司るニューロン移動の時空間的制御” 実験医学 vol.25(3) (企画)

梅島宏樹、見学美根子(2007)“神経細胞移動における中心体、核移動のダイナミクス” 実験医学 vol.25(3)、352-357.

永樂元次、見学美根子(2005)”小脳ニューロン・グリアの細胞形態形成を制御する細胞間相互作用” 神経研究の進歩 vol.49 「脳の発生分化と回路形成」、67-76.

見学美根子、梅嶋宏樹(2004)”小脳顆粒細胞の移動” 蛋白質核酸酵素増刊号 vol.49 「神経回路の機能発現のメカニズム」、255-260.

見学美根子(2003)”神経細胞の移動” 三輪書店「脳神経科学」(分筆)、177-188.

見学美根子(2002)”小脳の層形成と顆粒細胞の移動.” 実験医学増刊号 vol.20(5)「脳のパターン形成、神経ネットワーク、神経再生と臨床応用」(分筆)、97-104.

見学美根子(2000)”中枢神経系の発生と機能発現におけるWntシグナルの機能.” 細胞工学 19, 1650-1655.

見学美根子(1998)”WNT3aとWNT7aは同じシグナル伝達経路を介さない:ニワトリ肢芽形成におけるWNTファミリー分子の役割.” 細胞工学 17, 1408-1420.

岡本治正、見学美根子、本郷育子(1996)”神経誘導と形態形成の分子機構.” 蛋白質核酸酵素 41, 746-757.

岡本治正、見学美根子、本郷育子(1995)”初期発生における神経分化多様性の起源.” 神経研究の進歩 39, 756-765.